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KMID : 0358319950360020121
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Korean Journal of Urology
1995 Volume.36 No. 2 p.121 ~ p.127
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Interleukin-4 Receptor Expression on Human Renal Cell Carcinoma Cell Lines by a Reverse Transcription-Polymerase Chain Reaction
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천준
정동준/최종보/고성건/손정원
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Abstract
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Recently interleukin-4 (IL-4) has been suggested to be a promising therapeutic agent for the maligneant tumors of both murine and human origin. The effect of IL-4 is mediated by IL-4 receptor (IL-4R), which has been shown to be expressed in may
normal
and tumor cell lines. We herein tested two cell lines of human renal cell carcinoma (RCC), Caki-1 and CURC-II, for the expression of IL-4R gene. On the reverse transcritpion-polymerase chain reaction study, both cell lines expressed IL-4R mRNA.
The
present study suggests that it would be worthwhile to investigate the anti-tumor effect of IL-4 on Caki-1 and CURC-II, which may help to develop new therapeutic strategies for RCC using IL-4.
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KEYWORD
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